I dont know if this had been discovered before but i somehow found how curse relic works. in my todays comix harem run, after i defeated the first opponent , i chose curse relic   The good news is that it works. The bad news is it is penalizing rather than giving more advantage. we all know how damage is calculated :  Damage = (attacker attack - opponent defence) *2 but with curse relic , there will be no more *2 Damage = (attack - defence ) + ( % of curse)